Randomized consent designs for clinical trials: an update.
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                Source: Stat Med. 1990 Jun;9(6):645-56.
            
            
                DOI: 10.1002/sim.4780090611
                
                    Publication date: 
                    
                        1990 Jun
                    
                
                
                    E-Publication date: 
                    
                        Oct. 12, 2006
                    
                Availability: abstract
                Copyright: © 1990 John Wiley & Sons, Ltd.
            
            
                Language: English
                Countries: Not specified
                Location: Not specified
                Correspondence address: Not specified
            
        Keywords
Article abstract
Randomized consent designs were introduced to make it easier for physicians to enter patients in randomized clinical trials. Physician reluctance to participate in randomized clinical trials is often a reflection that the physician-patient relationship could be compromised if the physician makes known to the patient his/her inability to select a preferred therapy. Clinical trials having a no-treatment control or placebo amplify this concern. This paper reviews the main ideas of randomized consent designs (single and double) and the statistical model underlying the analysis, and presents some recent experiences.
 
                            