Low-salt water reduces intestinal permeability in atopic patients

Authors: Dupuy P (1) , Cassé M (1) , André F (2) , Dhivert-Donnadieu H (3) , Pinton J (4) , Hernandez-Pion C (4)
(1) Pierre Fabre Research Institute (2) Department of Digestive Immunopathology (3) Department of Pneumoallergy, Arnaud de Villeneuve’s Hospital (4) Avène Medical Spa Center
Source: Dermatology. 1999;198(2):153-5
DOI: 10.1159/000018092 Publication date: 1999 E-Publication date: April 26, 1999 Availability: abstract Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Language: English Countries: France Location: Not specified Correspondence address: patrick.dupuy@Pierre-fabre.com


Article abstract


Clinical remission of atopic dermatitis (AD) after intake of a low-salt water has recently been reported.


We here investigated the effects of a low-salt water in AD patients with increased intestinal permeability to lactulose. From an initial group of 75 atopic patients, who undertook a treatment in a medical spa center, 12 were included because of abnormal urinary excretion of lactulose (>0.6%), which is absorbed in the enterocytic interspaces, at baseline. The excretion of mannitol with an extraenterocytic absorption was also studied as control. During 18 days, the patients followed a medical spa treatment course, including topical application and oral ingestion of a low-mineral water. Patients were asked not to modify their usual food regimen during the cure. At the end of treatment (day 18), the determination of the excretion of both sugars in urine was repeated.


At baseline, the mean urine excretion of lactulose in the study population was 1.21+/-0.08 SEM. At the end of treatment (day 18), the lactulose concentration in urine diminished dramatically by 55% (mean 0.55+/-0.09 SEM, p = 0.0005). Urine mannitol was also found to be reduced over the cure period, although to a lesser extent (30%, p = 0.04).


This study indicates that low-mineral water normalizes the intestinal permeability of patients with AD.

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