Lessons from overviews of cardiovascular trials

Authors: Furberg CD (1) , Morgan TM (1)
(1) Center for Prevention Research and Biometry, Bowman Gray School of Medicine
Source: Stat Med. 1987 Apr-May;6(3):295-306
DOI: 10.1002/sim.4780060316 Publication date: 1987 Apr E-Publication date: Oct. 12, 2006 Availability: abstract Copyright: © 1987 John Wiley & Sons, Ltd
Language: English Countries: Not specified Location: Not specified Correspondence address: Not specified


Article abstract

Overviews of clinical trials in the cardiovascular field have been critically reviewed. Six reasons for the overviews were identified. An impression, at least from a scientific viewpoint, is that the pooled analyses have been valuable. Six potential problems are discussed and recommendations given based on lessons learned. These include the avoidance of three types of biases--publication bias, overviewer bias and investigator bias. The role of time-dependent treatment effects, the complex issue of 'mixing of apples and oranges' and the problem of errors are also addressed.

Find it online