Circulating opioid peptides during water immersion in normal man

Authors: Coruzzi P (1) , Ravanetti C (1) , Musiari L (1) , Biggi A (1) , Vescovi PP (2) , Novarini A (1)
(1) Istituto di Semeiotica Medica, University of Parma (2) Istituto di Clinica Medica Generale e Terapia Medica, University of Parma
Source: Clin Sci (Lond). 1988 Feb;74(2):133-6
DOI: 10.1042/cs0740133 Publication date: Feb. 1, 1988 E-Publication date: Not specified Availability: full text Copyright: © 1970 The Biochemical Society and the Medical Research Society
Language: English Countries: Not specified Location: Not specified Correspondence address: Not specified


Article abstract

1. This study was designed to evaluate variations in plasma β-endorphin, methionine-enkephalin, adrenocorticotropic hormone and serum prolactin in healthy volunteers during head-out water immersion.

2. Water immersion induced an increase in methionine-enkephalin plasma levels, which was associated with a significant fall in mean arterial pressure and heart rate.

3. Conversely, a suppression of plasma β-endorphin, adrenocorticotropic hormone and serum prolactin was detected during water immersion.

4. We suggest that a dopaminergic inhibitory control mechanism may be involved in regulating circulating levels of β-endorphin, adrenocorticotropic hormone and prolactin in normal subjects undergoing extracellular fluid volume expansion produced by water immersion.

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