Zinc and enzymes in the synovial fluid and blood in various types of rheumatism

Authors: Buneaux F , Buneaux JJ , Fabiani P , Galmiche P
Source: Rev Rhum Mal Osteoartic. 1978 Dec;45(12):699-701
DOI: Not specified Publication date: 1978 Dec E-Publication date: Not specified Availability: abstract Copyright: Not specified
Language: English Countries: Not specified Location: Not specified Correspondence address: Not specified



Article abstract

It appears that in rheumatoid arthritis and, to a lesser extent, in the other forms of inflammatory rheumatism, the level of zinc in the blood serum is lowered, whereas synovial zinc is increased. In the synovial fluid, there is a very significant correlation between enzyme activity and the concentration of zinc. Practical experiments aimed at demonstrating in vitro the action of zinc on lacticodeshydrogenase, acid phosphatase, lysozyme and beta-glucuronidase did not produce the anticipated results and do not explain the metabolic disorders of zinc seen during inflammatory rheumatisms.

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