Trace Elements in Serum and Urine of Patients with Rheumatoid Arthritis

Authors: Aaseth J (1,2,3) , Munthe E (1,2,3) , Førre Ø (1,2,3) , Steinnes E (1,2,3)
(1) Institute of Clinical Biochemistry (2) Sanitetsforenings Rheumatism Hospital (3) Institute of Atomic Energy
Source: Scand J Rheumatol. 1978;7(4):237-40
DOI: 10.3109/03009747809095662 Publication date: 1978 Aug E-Publication date: July 12, 2009 Availability: abstract Copyright: © 1978 Taylor & Francis
Language: English Countries: Not specified Location: Not specified Correspondence address: Not specified


Article abstract

Patients with rheumatoid arthritis were found to have elevated urinary copper excretion rates. They also had increased serum levels of coeruloplasmin and presumably also of a non-coeruioplasmin copper fraction. The zinc levels in serum and urine did not differ significantly from control values. Serum selenium and serum iron were decreased as compared with those of the healthy controls. It is suggested that an increased copper-to-selenium ratio may be of pathogenetic significance. Biochemical changes induced by copper may be antagonized (at least partly) by the treatment with gold thiomalate and D-penicillamine. If serum selenium deficiency in RA can be confirmed in larger materials, selenium supplementation as a therapeutic measure should be considered.

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