Topical application of CO2 increases skin blood flow.

Authors: Ito T (1) , Moore JI (1) , Koss MC (1)
(1) Department of Pharmacology, University of Oklahoma, Health Sciences Center
Source: J Invest Dermatol. 1989 Aug;93(2):259-62.
DOI: 10.1111/1523-1747.ep12277584 Publication date: 1989 Aug E-Publication date: Jan. 11, 2016 Availability: full text Copyright: © 1989 The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
Language: English Countries: Not specified Location: Not specified Correspondence address: Dr. T. Ito,
Department of Dermatology, Shinshu University School of Medicine, Matsumoto 390, Japan


Article abstract

The topical application of carbon dioxide water to the rat hindpaw produced a concentration-dependent increase of skin blood flow as measured by a laser Doppler flowmeter. About a 100% increase of skin blood flow occurred in response to CO2 when the bath temperature was at 23 degrees C or 34 degrees C, but there was no significant effect of CO2 at 41 degrees C. Carbon dioxide exposure also produced about the same increase of skin blood flow in the acutely or chronically denervated paw as in the control. These findings give experimental support for the clinical use of CO2 bathing in the treatment of disturbances of skin circulation as well as skin ulcers and wounds.

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