Penetration of selected Dead Sea minerals through a healthy rabbit skin, from a sustained-release transparent varnish, as a prospective treatment for psoriasis

Authors: Shani J (1) , Sulliman A (1) , Katzir I (1) , Brenner S (2)
(1) Dept. of Pharmacology, The Hebrew University School of Pharmacy (2) Department of Dermatology, Sourasky Medical Center
Source: Journal of the European Academy of Dermatology and Venereology Volume 4, Issue 3, June 1995, Pages 267–272
DOI: 10.1016/0926-9959(94)00028-X Publication date: 1995 Jun E-Publication date: March 10, 2000 Availability: abstract Copyright: © 1995 Published by Elsevier B.V.
Language: English Countries: Not specified Location: Not specified Correspondence address: Shani J : Department of Pharmacology, School of Pharmacy, The Hebrew University, P.O. Box 12065, Jerusalem 91120, Israel


Article abstract

Bathing in the Dead Sea is an established treatment for psoriasis. Penetration of Dead Sea minerals into psoriatic skin is an effective factor in this treatment, but applying it clinically requires frequent bathing in the Dead Sea or in its bath-salt solution. We tested an ethyl-cellulose-based transparent varnish with a sustained-release property, for its penetrability of such minerals. Minerals tested were MgBr2 and KBr, known for their relevance in psoriatic proliferation. They were applied for up to three weeks. We could demonstrate that two weekly applications of the salt-containing varnish on healthy rabbit skin are enough to obtain elevated levels of magnesium and potassium in their plasma. We propose the application of Dead Sea minerals containing varnish as a clinical treatment for psoriasis.

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