Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes.

Authors: Yunus MB (1)
(1) Section of Rheumatology, The University of Illinois College of Medicine
Source: Semin Arthritis Rheum. 2007 Jun;36(6):339-56
DOI: 10.1016/j.semarthrit.2006.12.009 Publication date: 2007 Jun E-Publication date: March 7, 2007 Availability: abstract Copyright: © 2007 Elsevier Inc. All rights reserved.
Language: English Countries: Not specified Location: Not specified Correspondence address: Yunus MB :


Article abstract


To discuss fibromyalgia syndrome (FMS) and overlapping conditions, eg, irritable bowel syndrome, headaches, and chronic fatigue syndrome, within the concept of central sensitivity syndromes (CSS).


A critical overview of the literature and incorporation of the author's own views.


The concept of CSS seems viable. It is based on mutual associations among the CSS conditions as well as the evidence for central sensitization (CS) among several CSS members. However, such evidence is weak or not available in other members at this time, requiring further studies. The biology of CSS is based on neuroendocrine aberrations, including CS, that interact with psychosocial factors to cause a number of symptoms.


CSS is an important new concept that embraces the biopsychosocial model of disease. Further critical studies are warranted to fully test this concept. However, it seems to have important significance for new directions for research and patient care involving physician and patient education. Each patient, irrespective of diagnosis, should be treated as an individual considering both the biological and psychosocial contributions to his or her symptoms and suffering.

Find it online