Repeated sauna therapy reduces urinary 8-epi-prostaglandin F(2alpha).

Authors: Masuda A (1) , Miyata M (1) , Kihara T (1) , Minagoe S (1) , Tei C (1)
(1) Department of Cardiology, Respiratory and Metabolic Medicine, Kagoshima University
Source: Jpn Heart J. 2004 Mar;45(2):297-303.
DOI: 10.1536/jhj.45.297 Publication date: 2004 Mar E-Publication date: April 14, 2004 Availability: full text Copyright: © 2004 by the Japanese Heart Journal
Language: English Countries: Japan Location: Olympia Co. Correspondence address: Chuwa Tei, MD,
Department of Cardiology, Respiratory and Metabolic Medicine, Kagoshima
University, 8-35-1, Sakuragaoka, Kagoshima 890-8520, Japan


Article abstract

We have reported that repeated sauna therapy improves impaired vascular endothelial function in a patient with coronary risk factors. We hypothesized that sauna therapy decreases urinary 8-epi-prostaglandin F(2alpha) (PGF(2alpha)) levels as a marker of oxidative stress and conducted a randomized, controlled study. Twenty-eight patients with at least one coronary risk factor were divided into a sauna group (n = 14) and non-sauna group (n = 14). Sauna therapy was performed with a 60 degrees C far infrared-ray dry sauna for 15 minutes and then bed rest with a blanket for 30 minutes once a day for two weeks. Systolic blood pressure and increased urinary 8-epi-PGF(2alpha) levels in the sauna group were significantly lower than those in the non-sauna group at two weeks after admission (110 +/- 15 mmHg vs 122 +/- 13 mmHg, P < 0.05, 230 +/- 67 pg/mg x creatinine vs 380 +/- 101 pg/mg x creatinine, P < 0.0001, respectively). These results suggest that repeated sauna therapy may protect against oxidative stress, which leads to the prevention of atherosclerosis.

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