The Effect of Mofettes on Oxidative Stress/Antioxidant Balance in Experimental Myocardial Ischemia

Authors: Dogaru G (1) , Bulboacă A (1) , Boarescu PM (1) , Rus V (2) , Sitar-Taut AV (1) , Munteanu C (3) , Stănescu I (1)
(1) “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca (2) University of Agricultural Sciences and Veterinary Medicine (3) Romanian Balneology Association
Source: In vivo (Athens, Greece) 33(6)
DOI: 10.21873/invivo.11685 Publication date: Not specified E-Publication date: 2019 Oct Availability: full text Copyright: Not specified
Language: English Countries: Romania Location: Not specified Correspondence address: Vasile Rus, Department of Cell Biology,Histology and Embryology,University of Agricultural Sciences andVeterinary Medicine, Calea Manastur Str. No 3-5, Cluj-Napoca400375, Romania. Tel: +40 264596384 int 266,


Article abstract

Background/aim: Natural mofettes are gases resulting from post-volcanic emanations. This study aimed to examine the effect of mofette therapy on plasma oxidative stress and antioxidant parameters in rats after experimental induction of myocardial ischemia, as well as on structural changes in myocardial tissue. Materials and methods: White Wistar-Bratislava rats were divided into three groups. In groups 2 and 3, myocardial ischemia was induced by isoproterenol. Rats in group 3 were additionally exposed to high levels mofettes. Oxidative stress and antioxidant parameters were determined in plasma. The structural changes of the myocardium were observed in paraffin embedded slices contrasted using Goldner's trichrome staining. Results: A statistically significant change in serum oxidative stress biomarkers, including nitric oxide, malondialdehyde, total oxidant status, as well as in the tested antioxidant molecules and total antioxidant capacity were observed in group 3 compared to group 2. Also, rats of group 3 showed an obvious improvement in inflammatory infiltration and repair of necrotic areas through collagen proliferation (proliferation of fibrous connective tissue) compared to group 2. Conclusion: Mofette had a beneficial effect on the balance between oxidative stress and antioxidant status following experimentally induced myocardial ischemia.

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