Balneotherapy decreases mechanical hyperalgesia by reversing BDNF and NOS2 immunocontent in spinal cord of mice with neuropathic pain

Authors: de Brito RN (1,2) , Ludtke DD (1,2) , de Oliveira BH (1,2) , de Oliveira Galassi T (1,2) , Fernandes PF (1,2) , Van Den Berge S (1) , Salgado AS (1,2,3) , Cidral-Filho FJ (1,2) , Horewicz VV (1,2) , Bobinski F (1,2) , Martins DF (1,2)
(1) Experimental Neuroscience Laboratory (LaNEx), Universidade do Sul de Santa Catarina (2) Postgraduate Program in Health Sciences, Universidade do Sul de Santa Catarina (3) Integrative Physical therapy Residency, Centro Universitário Filadélfia
Source: J Neuroimmunol . 2020 Aug 16;348:577360
DOI: 10.1016/j.jneuroim.2020.577360 Publication date: Not specified E-Publication date: Aug. 16, 2020 Availability: abstract Copyright: © 2020 Elsevier B.V. All rights reserved.
Language: English Countries: Brazil Location: Santo Amaro da Imperatriz Correspondence address:


Article abstract

In the last decades, balneotherapy or thermalism has been used for health promotion and in the treatment of inflammatory and chronic processes. We found that balneotherapy reduced mechanical hyperalgesia, as well the increase of BDNF and NOS2 levels in the spinal cord, while increased BDNF and NOS1 in the paw. The data presented herein demonstrated for the first time in a murine model of neuropathic pain, the analgesic effect of balneotherapy with the water from the natural springs of Santo Amaro da Imperatriz-Brazil. Nevertheless, future clinical trials should be conducted to test the effectiveness of balneotherapy in neuropathic pain patients.

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