Effects of mineral water from spring 3 in Băile Tuşnad on experimentally induced alcoholic liver disease

Authors: Dogaru G (1,2) , Motricală M (3) , Molnar A (3) , Rus V (4)
(1) “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca (2) Clinical Rehabilitation Hospital Cluj-Napoca (3) Tușnad Spa Complex-Băile Tușnad (4) University of Agricultural Sciences and Veterinary Medicine
Source: Balneo Research Journal
DOI: 10.12680/balneo.2017.147 Publication date: Not specified E-Publication date: 2017 Sep Availability: full text Copyright: Not specified
Language: English Countries: Not specified Location: Not specified Correspondence address: Not specified


Article abstract

Chronic alcohol consumption leads to the development of specific disorders, particularly of the liver. In this study, we aimed to investigate by optical microscopy the hepatic changes occurring after administration of ethyl alcohol for 70 days to Wistar rats, as well as the curative effect of mineral water from spring 3 in Băile Tuşnad administered for 50 days after completion of ethyl alcohol administration. Liver fragments were harvested and histologically processed by paraffin embedding and stained with Goldner’s trichrome method. After the first 70 days of the experiment, in the liver parenchyma, fat loading of hepatocytes and mild perivascular fibrosis were identified. After another 50 days, during which some of the rats drank tap water, the pathological evolution did not seem to stop, but on the contrary, a slight aggravation could be observed, while in rats drinking Tuşnad mineral water there was an arrest of evolution and a slight regression of the described aspects. This study evidences the curative effect of mineral water from spring 3 in Băile Tuşnad on alcoholic liver disease.

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