Effects of sulphur-containing mineral water intake on oxidative status and markers for inflammation in healthy subjects

Authors: Sokrateva TD (1) , Roussev BH (1) , Nashar MA (1) , Kiselova-Kaneva YD (1) , Mihaylova GM (1) , Todorova MN (1) , Pasheva MG (1) , Tasinov OB (1) , Nazifova-Tasinova NF (1) , Vankova DG (1) , Ivanova DP (1) , Radanova MA (1) , Ts Galunska B (1) , Vlaykova TI (2) , Ivanova DG (1)
(1) a Department of Biochemistry, Molecular Medicine and Nutrigenomics , Medical University-Varna (2) Department of Chemistry and Biochemistry, Medical Faculty , Trakia University
Source: Arch Physiol Biochem
DOI: 10.1080/13813455.2019.1638416 Publication date: Not specified E-Publication date: July 11, 2019 Availability: abstract Copyright: Not specified
Language: English Countries: Bulgaria Location: Not specified Correspondence address: Not specified


Article abstract

Context: Sulphurous mineral waters (SMW) have a wide range of applications. Sulphur content of mineral waters is considered as possible determinant for their anti-inflammatory or pro-inflammatory effects. Objective: To explore the healing properties of Varna basin mineral water by analysing possible antioxidative and anti-inflammatory effects. Materials and methods: An intervention with Varna SMW intake was performed with healthy volunteers. Total thiols, total glutathione and its fractions, reactive oxygen metabolites, malondialdehyde, intracellular adhesion molecule (ICAM-1) and vascular cell adhesion molecule (VCAM-1) were measured. Expression of γ-gluthamyl-cysteinyl ligase (GCL) and sICAM-1 genes was also analysed. Results: A significantly increased total glutathione and total thiols were observed at the end of the intervention. GCL and sICAM-1 gene expressions were increased after the intervention. Conclusion: SMW consumption improved redox status of the body. We suggested that these beneficial effects may be attributed to the established high levels of sulphur-containing compounds in Varna mineral water.

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