Influence of mineral waters on in vitro proliferation, antioxidant response and cytokine production in a human lung fibroblasts cell line

Authors: Melgar-Sánchez LM (1) , García-Ruiz I (2) , Pardo-Marqués V (2) , Agulló-Ortuño MT (2,3) , Martínez-Galán I (3)
(1) Department of Medical Sciences, Faculty of Medicine, Universidad de Castilla-La Mancha (2) Laboratory of Clinical and Translational Oncology, Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12) (3) Department of Nursing, Physiotherapy and Occupational Therapy, School of Nursing and Physiotherapy, Universidad de Castilla-La Mancha
Source: Int J Biometeorol.
DOI: 10.1007/s00484-019-01730-0 Publication date: Not specified E-Publication date: June 21, 2019 Availability: abstract Copyright: © ISB 2019
Language: English Countries: Spain Location: Ledesma, Paracuellos and Archena spas Correspondence address:


Article abstract

Spa mineral waters are used for the treatment of chronic diseases' symptoms. Anti-inflammatory, analgesic, anti-ageing and tissue repair effects have been attributed to them. This work seeks to improve knowledge about the effect of spa mineral waters on human cells. For this, human lung fibroblasts were treated with mineral waters from Ledesma, Paracuellos and Archena spas, three Spanish health resorts with different water chemical composition. A significant increase of cell proliferation together with an enhanced antioxidant capacity (reactive oxygen and nitrogen species, glutathione levels and superoxide dismutase activity) in mineral water-treated fibroblasts compared to control fibroblasts was observed. Moreover, cytokine profiling revealed an increase in the release of MIF, IL-6, CL-1, CCL-5 and ICAM-1, which are described as mediators in proliferation, wound healing and cell migration processes. In conclusion, our results could be in line with the effects attributed to spa mineral waters in wound healing strategies and oxidative damage protection.

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