Analgesic effect of mineral cream containing natural spa minerals for use on the skin

Authors: Hirabayashi T (1) , Yamashita M (1,2) , Wada N (1) , Takenoya F (2) , Ikeda H (3) , Kamei J (3) , Ryushi T (4) , Yamamoto N (5) , Shioda S (1)
(1) Global Research Center for Innovative Life Science (2) Department of Exercise and Sports Physiology, School of Pharmacy and Pharmaceutical Sciences (3) Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences (4) Faculty of Sports and Health Science, Department of Sports Science (5) Department of Health Sciences
Source: Biomed Res. 2018;39(4):215-222
DOI: 10.2220/biomedres.39.215 Publication date: Not specified E-Publication date: Aug. 1, 2018 Availability: full text Copyright: © 2018 Biomedical Research Press
Language: English Countries: Not specified Location: Not specified Correspondence address: Not specified


Article abstract

Previous studies have shown that dissolved substances in some natural hot springs have analgesic/anti-nociceptive and anti-inflammatory actions. However, the mechanisms underlying how such dissolved substances exert these actions are not fully understood. In the present study on mice, we examined the analgesic/anti-nociceptive and anti-inflammatory properties of a mineral cream containing natural hot spring ingredients. The anti-nociceptive effects of the mineral cream were assessed by using the von Frey test. Application of the mineral cream to the hind paw of mice produced a significant anti-nociceptive effect compared to control. The anti-nociceptive effects of the mineral cream were also assessed following the injection of complete Freund's adjuvant (CFA) into the hind paws of mice after pre-treatment for one or four weeks with the mineral cream. Histological experiments with light microscopy showed that the mineral cream did not reduce inflammation caused by the CFA treatment. In addition, the mineral cream did not inhibit oxidative stress as evidenced by increased levels of oxidative metabolites (d-ROMs) and biological anti-oxidant potential (BAP). These results suggest that the mineral cream does not exert a protective effect against inflammation, and that the constituents of the mineral cream may produce their anti-nociceptive effects transdermally via different mechanisms including the nervous system.

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