Long-term improvement of breast cancer survivors' quality of life by a 2-week group physical and educational intervention: 5-year update of the 'PACThe' trial

Authors: Kwiatkowski F (1) , Mouret-Reynier MA (2) , Duclos M (3) , Bridon F (4) , Hanh T (5) , Van Praagh-Doreau I (2) , Travade A (6) , Vasson MP (7) , Jouvency S (7) , Roques CF (8) , Bignon YJ (9)

Affiliations:

(1) Department of Clinical Research, Comprehensive Anticancer Centre Jean Perrin (2) Department of Oncology, Comprehensive Anticancer Centre Jean Perrin (3) Gabriel Montpied University Hospital, Department of Sport Medicine and Functional Explorations (4) Institut de Formation des Masseurs-Kinésithérapeutes, Centre Hospitalier Lacarin (5) Centre Nutritionnel de Vichy (6) Centre République, Department of Senology, Clermont Ferrand (7) Department of Nutrition, Comprehensive Anticancer Centre Jean Perrin (8) University of Toulouse, Physical Medicine and Reeducation, Toulouse, France (9) Department of Oncogenetics, Comprehensive Anticancer Centre Jean Perrin

Source: Br J Cancer. 2017 Apr 20

Language: English Countries: France Location: Not specified Correspondence address: Not specified

Keywords

Article abstract

BACKGROUND:

The advantages of adapted physical activity and nutritional education (APANE) on breast cancer prognosis and quality of life (QoL) are well known, but long-term results are lacking.

METHODS:

A randomised controlled trial testing a 2-week intervention in hydrothermal centres including APANE enrolled 251 patients post-chemotherapy. QoL and weight control were significantly improved at 12 months. A 5-year follow-up was performed to evaluate the persistence of improvements.

RESULTS:

QoL increase (SF36) was persistent: effect-size at 2, 3, 4 and 5 years equalled respectively 0.27 (-0.01; 0.56), 0.28 (-0.02; 0.58), 0.41 (0.02; 0.81) and 0.45 (0.11; 0.80). Weight control observed after intervention lasted 2 years: 2.7% decrease at 1 year (P=0.0085), 2.5% at 2 years (P=0.025); and respectively for waist -2.4% (-3.6; -1.1) (P=0.000014) and -1.3% (-2.5; -0.1) (P=0.0072).

CONCLUSIONS:

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